Induction of pluripotent stem cells from autopsy donor-derived somatic cells
نویسندگان
چکیده
منابع مشابه
Induced pluripotent stem cell lines derived from human somatic cells.
Somatic cell nuclear transfer allows trans-acting factors present in the mammalian oocyte to reprogram somatic cell nuclei to an undifferentiated state. We show that four factors (OCT4, SOX2, NANOG, and LIN28) are sufficient to reprogram human somatic cells to pluripotent stem cells that exhibit the essential characteristics of embryonic stem (ES) cells. These induced pluripotent human stem cel...
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The concept of reprogramming of somatic cells has opened a new era in regenerative medicine. Transduction of defined factors has successfully achieved pluripotency. However, during the generation process of induced pluripotent stem (iPS) cells, genetic manipulation of certain factors may cause tumorigenicity, which limits further application. We report that that a single transfer of embryonic s...
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1National Research Laboratory for Cardiovascular Stem Cell, 2Cardiovascular Center and Department of Internal Medicine, and 3Innovative Research Institute for Cell Therapy, Seoul National University Hospital, Seoul; 4Division of Integrative Biosciences and Biotechnology, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang; 5Medical Genomics Research Cent...
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ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 2011
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2011.07.048